Regenerative medicine may be considered for selected joint, tendon, ligament, SI joint, foot, pelvic, or hypermobility-related pain patterns.
Learn how Dr. Siefferman explains regenerative medicine, including advanced treatments designed to support the body's natural healing process and help reduce chronic pain.
Our team organizes conditions and treatments into related zones of expertise to make it easier to explore the care paths most relevant to your symptoms and goals.
Use the zone tags above to browse dedicated pages for each focus area, including services, providers, and what to expect during treatment.
Hi, I’m Dr. Jason Siefferman, medical director at 91视频. When we’re looking at a painful structure where there has been some injury, we question how can we best heal the structure. Will it heal on its own? Has it failed to heal on its own? Will physical therapy be adequate? Or do we need to do something to bolster that healing process?
Regenerative medicine is a category of injections where we actually stimulate a healing response through the body’s natural inflammatory cascade. And we generally have two or three main modalities that we use for this.
First, prolotherapy. Prolotherapy stands for proliferation therapy. We do this with dextrose, which is sugar. What the sugar does is it chemically irritates the tissues and stimulates a healing response directly. What’s nice about prolotherapy is that we can include local anesthetic with it. So, we also achieve a diagnostic block, which means we can confirm if that structure is indeed causing the pain we think it is. Any pain coming from that structure will be gone because it’s numb. If patients respond to prolotherapy, fantastic. This is something we can do a series of and we should see sequential improvement with each injection.
PRP is a more robust option. This is where we draw the patient’s blood, spin it down, we get the platelets, then we inject those platelets directly into the injured structures. This cannot be combined with local anesthetic because it actually deactivates the platelets. It is much more uncomfortable. It’s also a little bit more expensive because there’s a process of drawing the blood and spinning it down.
The healing effect from PRP is generally more robust than prolotherapy. So if there’s a torn meniscus or a labrum, PRP is generally a better choice for these, meaning you can get a more durable healing response with fewer injections. After PRP, of course, there’s bone marrow aspirate concentrate. There are other more advanced regenerative techniques, but generally if the first two are used appropriately, we don’t need to escalate to the more extravagant or expensive. Although many people are interested in stem cells, they’re generally not necessary.
By understanding, reverse engineering the mechanical cascade of why the pain is generating, we can identify the structures that need to be treated, choose the best treatment for those structures, and then get the patient to a healed place. By reverse engineering the process, understanding the mechanics that are causing the ongoing injury or lack of healing and treating those directly, specifically with the best form of regenerative medicine, we can generally help the patient find healing.
Regenerative medicine is a treatment category that may include procedures such as platelet-rich plasma, prolotherapy, and bone marrow aspirate concentrate for selected musculoskeletal, ligament, tendon, joint, spine-adjacent, pelvic, foot, or hypermobility-related pain patterns.
At 91视频, regenerative medicine NYC care is not presented as a cure-all, a guaranteed alternative to surgery, or a replacement for diagnosis. Treatment begins with a careful evaluation of the pain generator, anatomy, imaging, prior treatments, functional goals, and whether the patient is an appropriate candidate for a regenerative or orthobiologic approach.
MPM specialists evaluate whether regenerative medicine may be appropriate by identifying the likely source of pain before recommending a procedure. Joint pain, tendon pain, ligament pain, spine-adjacent pain, SI joint pain, foot pain, pelvic pain, and hypermobility-related symptoms can have different causes and may not respond to the same treatment.
MPM reviews the diagnosis, exam findings, imaging, prior injections, physical therapy response, instability patterns, inflammation, nerve involvement, and functional goals. This helps determine whether PRP, prolotherapy, BMAC, rehabilitation, medication management, ultrasound-guided injections, or another care pathway may be more appropriate.
Many patients search for regenerative medicine in Manhattan after trying physical therapy, medications, steroid injections, bracing, rest, orthopedic care, or surgery consultation without enough improvement. Others are specifically looking for PRP, prolotherapy, BMAC, orthobiologics, or alternatives to 鈥渟tem cell鈥� procedures.
MPM approaches regenerative medicine carefully. Some options, such as platelet-rich plasma, prolotherapy, and bone marrow aspirate concentrate, may be considered for selected musculoskeletal or soft tissue pain patterns when the diagnosis and target are appropriate. However, regenerative medicine is not appropriate for every patient, and results vary. MPM avoids unsupported claims about cartilage regrowth, ligament reconstruction, disc regeneration, nerve regeneration, or guaranteed surgery avoidance. Many marketed stem cell, exosome, amniotic, cord-derived, and similar products are not FDA-approved for orthopedic pain or chronic pain conditions. MPM focuses on informed consent, realistic expectations, precise targeting, and coordinated rehabilitation when appropriate.
Regenerative medicine may intersect with several MPM Zones of Expertise, including Musculoskeletal issues, Hypermobility, Complex Chronic Pain, and Pelvic Pain. In musculoskeletal care, regenerative procedures may be considered for selected joint, tendon, ligament, chronic sprain, SI joint, foot, or spine-adjacent pain patterns. In hypermobility and EDS-related pain, treatment planning may focus on instability, ligament strain, compensatory muscle guarding, and realistic functional goals.
For pelvic pain, pudendal neuralgia overlap, pelvic floor dysfunction, or peripheral pain patterns, regenerative medicine may be considered only when the target and diagnosis support it. For complex chronic pain, MPM also evaluates whether central sensitization, post-viral symptoms, fibromyalgia, inflammation, or nerve pain may be contributing. Regenerative medicine is one possible tool, not the entire care plan.
Before regenerative medicine treatment, MPM reviews the diagnosis, target structure, procedure type, expected goals, risks, alternatives, and recovery plan. Depending on the treatment, the procedure may involve PRP prepared from the patient鈥檚 own blood, prolotherapy solution, BMAC collected and processed from bone marrow, or another carefully selected approach. Ultrasound guidance may be used when appropriate to help target the selected area.
Patients may feel pressure, soreness, or a temporary pain flare after treatment. Recovery varies by procedure, target, and diagnosis. Some patients may need to modify activity, avoid certain medications, use bracing, or begin a gradual rehabilitation plan. Relief, if it occurs, may be gradual and is not guaranteed. MPM monitors response, function, side effects, and whether the next step should involve additional treatment, rehabilitation, imaging, or another care pathway.
I cannot say enough good things about 91视频. From the moment I walked in, I felt truly cared for and taken seriously. Dr. Nino Mikaberidze, Director of Rheumatology, is exceptional 鈥� knowledgeable, compassionate, and incredibly thorough. She takes the time to listen, explains every...
The best care I've received as a chronic pain patient. I traveled from out of state to visit 91视频 because I could not find knowledgeable doctors in my hometown for my hypermobility, and Ehlers-Danlos syndrome symptoms and comorbidities. Let me tell you, it was worth every travel e...
I was injured in a bicycle accident over 8 years ago. I鈥檝e suffered throughout the years since my accident with nothing seeming to work. PT, Yoga, lifestyle changes, NOTHNG! I finally made an appointment with Dr Kane and I鈥檓 feeling an improvement in my life. I no longer stay up all night in pain, a...
One of the best experiences, if not the best, I have ever had at the doctor鈥檚 office. From the front desk to the nurses to the PA assisting the doctor this was a great experience. Dr.Nino actually listened to me and came up with a game plan. Would recommend this practice to as many people as I could...
I have very unique & severe nerve pain from CRPS which has no known specific cure. Dr. Siefferman has a huge tool box, far greater than the other 23 Drs. I have seen. He saved me from jumping off a bridge and continues to help me with both treatments and advice. Dr. S. is in a different league!
After two years of searching and feeling lost and let down, I finally found real help at 91视频. With Dr. Siefferman, Adam Rosenberg, Dr. Mikaberidze, and the whole team, I feel heard, supported and understood. Every symptom is being considered and I鈥檓 finally getting answers with m...
Why is Dr Dr. Tayyaba Ahmed one of the top pevic Floor specialists - 1- She wants to know a full history of what led the patient to get to this point. 2 - She listens intensley to the patient 3- She does not rush you 4- Extremely skilled at giving pelvic floor injections 5- I thank my luck stars she...
The staff was friendly and helpful. Dr. Siefferman was thoughtful, listened, asked questions and proposed simple safe ways to come to further conclusions regarding my pain and discomfort. The office staff including Dr. Siefferman is responsive even after the initial in-person visit. Very pleased.
Dr. Siefferman is a brilliant provider. While my pain is still a work in progress, Dr Siefferman always gives me options and explains his reasoning behind things. He listens to my feedback and concerns. I never feel rushed; and am grateful he works to meet me where I am. I highly recommend him.
What a great find! They listen to me, I listen to them and the diagnosis is made and a plan developed to develop an approach to treat all of my chronic pain. I wish I could have discovered this type of treatment sooner. This doctor and group give me hope.
Regenerative medicine is a treatment category that may include procedures intended to support tissue healing, reduce irritation, or improve function in selected musculoskeletal pain conditions. In pain care, this may include platelet-rich plasma, prolotherapy, bone marrow aspirate concentrate, or other orthobiologic approaches when clinically appropriate. Regenerative medicine is not a cure-all and is not appropriate for every pain condition. At MPM, regenerative medicine is considered only after diagnosis-first evaluation, target selection, safety review, and discussion of realistic expectations.
Orthobiologics are biologic materials used in orthopedic or musculoskeletal care to support healing or tissue response in selected conditions. Examples may include platelet-rich plasma and bone marrow concentrate when used appropriately. The term is broad and can be confusing because not all marketed products are supported by strong evidence or approved for orthopedic pain conditions. MPM uses cautious, medically grounded language and evaluates whether an orthobiologic option fits the diagnosis, tissue target, and treatment goal.
No. Regenerative medicine is a broad category, and not all regenerative treatments are stem cell therapy. PRP, prolotherapy, and BMAC are different procedures with different materials, goals, and evidence. Many marketed 鈥渟tem cell,鈥� exosome, amniotic, Wharton鈥檚 jelly, cord blood, or adipose-derived products are not FDA-approved for orthopedic pain or chronic pain conditions. MPM does not rely on unsupported claims and does not present stem cell therapy as a routine or guaranteed solution for musculoskeletal pain.
PRP stands for platelet-rich plasma. It is prepared from a patient鈥檚 own blood and processed to concentrate platelets before injection into a selected tissue target. PRP may be considered for certain tendon, ligament, joint, or soft tissue pain patterns when the diagnosis supports it. PRP is not appropriate for every condition and does not guarantee healing or pain relief. MPM evaluates the pain generator, imaging, prior treatments, and recovery plan before considering PRP treatment NYC care.
Prolotherapy is an injection-based treatment that may be considered for selected ligament, tendon, joint, or instability-related pain patterns. It typically involves injecting a solution into a targeted area to stimulate a local tissue response. Prolotherapy is not a general pain treatment and is not appropriate for every patient. MPM evaluates whether symptoms are related to ligamentous laxity, chronic sprain, joint instability, SI joint dysfunction, or another target before considering prolotherapy in NYC.
BMAC stands for bone marrow aspirate concentrate. It is prepared from a patient鈥檚 own bone marrow and processed before being injected into a selected target. BMAC may be considered in certain orthopedic or musculoskeletal contexts, but it is not a guaranteed regenerative solution and should not be described as a cure. MPM evaluates diagnosis, target tissue, medical history, regulatory considerations, safety, evidence limits, and treatment alternatives before considering BMAC treatment NYC care.
Steroid injections are typically used to reduce inflammation and pain in a targeted area. Regenerative medicine procedures, such as PRP, prolotherapy, or BMAC, are intended to support tissue response or healing pathways in selected cases. They have different goals, risks, timelines, and recovery expectations. Steroids may work more quickly in some inflammatory situations, while regenerative procedures may involve a slower response. MPM determines which approach, if any, fits the diagnosis and patient goals.
Regenerative medicine may be considered for selected joint pain patterns, depending on the diagnosis, severity, tissue target, and goals. It may be relevant for some patients with joint irritation, mild to moderate degenerative changes, instability, or soft tissue contributors. It is not a cure for arthritis, joint degeneration, hypermobility, or chronic pain. MPM evaluates whether the pain is coming from the joint itself, surrounding ligaments or tendons, inflammation, nerve irritation, or another source before recommending treatment.
Regenerative medicine may be considered for selected tendon or ligament pain patterns, including some cases of tendinopathy, chronic sprain, ligament strain, or instability-related pain. The right option may differ depending on whether the problem involves tendon degeneration, ligament laxity, partial injury, overuse, inflammation, or poor movement mechanics. MPM evaluates the tissue target carefully and may use diagnostic ultrasound, imaging review, ultrasound-guided injections, physical therapy planning, or bracing recommendations as part of care.
Regenerative medicine may be considered for selected patients with hypermobility or EDS-related pain when a specific ligament, joint, tendon, or instability-related target is identified. It is not a cure for EDS, hypermobility spectrum disorder, joint instability, or complex chronic pain. Patients with hypermobility often need coordinated care that may include stabilization, bracing, physical therapy, pacing, medication management, and evaluation for overlapping nerve or central pain contributors. MPM evaluates candidacy carefully before recommending regenerative treatment.
Regenerative medicine may be considered for selected spine-adjacent or SI joint pain patterns when the suspected pain generator is appropriate for treatment. SI joint pain may be mechanical, inflammatory, hypermobility-related, degenerative, or referred from the spine. Spine pain may involve discs, facets, nerves, ligaments, muscles, instability, or central sensitization. MPM evaluates the diagnosis carefully before considering regenerative medicine for spine pain, SI joint pain, or related symptoms. Other imaging, injections, rehabilitation, or surgical evaluation may be needed.
Regulatory status depends on the specific product or procedure. Some autologous procedures, such as PRP or BMAC, may be used in selected clinical contexts, but many marketed regenerative products are not FDA-approved for orthopedic pain or chronic pain conditions. This includes many stem cell, exosome, amniotic, cord blood, Wharton鈥檚 jelly, or adipose-derived products promoted for pain. MPM avoids unsupported claims and discusses evidence, regulatory concerns, risks, and alternatives before recommending treatment.
Coverage varies by procedure, diagnosis, insurer, and medical policy. Many regenerative medicine procedures, including PRP, prolotherapy, and BMAC, may not be covered by insurance or may be considered investigational for certain indications. Patients should verify coverage, out-of-pocket costs, and authorization requirements before treatment. MPM can help clarify the clinical rationale for treatment, but insurance decisions depend on the payer and specific policy.
MPM considers the diagnosis, pain generator, tissue target, imaging, exam findings, prior treatments, medical history, activity goals, instability patterns, inflammatory disease, nerve involvement, and whether rehabilitation is part of the plan. The team also considers whether another treatment should come first, such as diagnostic ultrasound, ultrasound-guided injections, physical therapy, medication management, rheumatology care, neurology care, pelvic specialty evaluation, or surgical consultation. Regenerative medicine is recommended only when the clinical picture supports it.
Risks may include post-procedure pain flare, bruising, bleeding, infection, allergic reaction, nerve irritation, vascular injury, incomplete relief, temporary worsening, and persistent symptoms despite treatment. Some procedures may involve additional risks depending on the target and material used. Regenerative medicine does not guarantee pain relief or healing. MPM reviews risks, expected recovery, alternatives, and follow-up needs before treatment. Urgent evaluation is needed for fever, spreading redness, severe swelling, new weakness, new numbness, loss of pulses, limb discoloration, or rapidly worsening symptoms.
Before care begins, our team helps patients understand the practical side of treatment, including insurance verification, out-of-network benefits, cost-share estimates, self-pay options, and billing questions. We believe patients should have as much clarity as possible before moving forward.
Jason W. Siefferman, MD
Jason W. Siefferman, MD
MPM
Regenerative medicine is a broad category of treatments that may be considered for selected musculoskeletal, tendon, ligament, joint, spine-adjacent, SI joint, foot, pelvic-region, and hypermobility-related pain patterns. Commonly discussed options include platelet-rich plasma, prolotherapy, and bone marrow aspirate concentrate. These procedures are sometimes called orthobiologics when they use biologic materials in musculoskeletal care.
At 91视频 (MPM), regenerative medicine NYC care begins with diagnosis-first evaluation. The goal is to determine whether the patient has a clear pain generator that may reasonably respond to a regenerative approach. Regenerative medicine is not a cure-all, a guaranteed alternative to surgery, or a replacement for rehabilitation, medical management, or appropriate specialist care.
PRP, or platelet-rich plasma, is prepared from a patient鈥檚 own blood and processed to concentrate platelets before injection into a selected target. It may be considered for certain tendon, ligament, joint, or soft tissue pain patterns when the diagnosis supports it.
Prolotherapy is an injection-based treatment that may be considered for selected ligament, tendon, joint, or instability-related pain patterns. It is sometimes discussed in the context of chronic sprains, joint instability, SI joint pain, or hypermobility-related symptoms when a specific target is identified.
BMAC, or bone marrow aspirate concentrate, is prepared from the patient鈥檚 own bone marrow and processed before injection into a selected area. It may be considered in certain orthopedic or musculoskeletal contexts, but it should not be described as guaranteed tissue regeneration or a cure.
Standard pain injections often use medications such as local anesthetic or corticosteroid to reduce pain, inflammation, or irritation in a targeted area. Regenerative procedures have a different goal. They are intended to support a tissue response in selected cases, and the response may be slower or more variable.
This difference is important. A steroid injection may be more appropriate for certain inflammatory conditions. A regenerative procedure may be considered when a tendon, ligament, joint, or instability-related target fits the diagnosis. In some cases, diagnostic ultrasound or diagnostic injections may be needed before deciding whether regenerative medicine is reasonable.
Patients with EDS, hypermobility spectrum disorder, joint instability, chronic sprains, or ligament-related pain often ask whether regenerative medicine can help. For selected patients, regenerative injections may be considered when a specific ligament, tendon, or joint target is contributing to symptoms.
However, regenerative medicine does not cure EDS or hypermobility. These conditions often require stabilization, bracing, gradual strengthening, pacing, activity modification, medication management, and evaluation for overlapping nerve pain, central sensitization, or autonomic symptoms. MPM evaluates whether a regenerative procedure could support the care plan or whether rehabilitation and stabilization should be prioritized.
Regenerative medicine may be considered for selected SI joint pain, spine-adjacent ligament or soft tissue pain, foot pain, tendon pain, and peripheral pain patterns when the target is clear. SI joint pain may be mechanical, inflammatory, hypermobility-related, degenerative, or referred from the spine. Foot pain may involve tendons, ligaments, Morton鈥檚 neuroma, tarsal tunnel syndrome, metatarsalgia, or other contributors. Pelvic pain may involve pelvic floor dysfunction, pudendal neuralgia, pelvic dystonia, or peripheral structures, but regenerative medicine is only considered when a specific target and rationale are present.
Some conditions require other pathways first, including advanced imaging, diagnostic ultrasound, nerve evaluation, rheumatology care, neurology care, pelvic specialty care, or surgical consultation.
Regenerative medicine is an evolving field. Some therapies may help pain and function in selected patients, but results vary and evidence differs by condition and procedure. MPM avoids unsupported claims about cartilage regrowth, ligament reconstruction, disc regeneration, nerve regeneration, or guaranteed avoidance of surgery.
Patients should be cautious about marketed 鈥渟tem cell,鈥� exosome, amniotic, cord-derived, Wharton鈥檚 jelly, or adipose-derived products promoted for orthopedic pain or chronic pain. Many of these products are not FDA-approved for those uses. MPM focuses on appropriate patient selection, informed consent, and realistic expectations.
Risks may include post-procedure pain flare, bruising, bleeding, infection, allergic reaction, nerve irritation, vascular injury, incomplete relief, temporary worsening, and persistent symptoms despite treatment. Recovery may require activity modification, bracing, gradual loading, rehabilitation, and follow-up assessment.
Patients should seek urgent evaluation for fever, spreading redness, severe swelling, new weakness, new numbness, bowel or bladder dysfunction, saddle anesthesia, chest pain, shortness of breath, sudden severe headache, severe abdominal or pelvic pain, major trauma, suspected infection, loss of pulses, limb discoloration, or rapidly worsening symptoms.
For selected patients, regenerative medicine may be one part of a targeted pain care plan. MPM鈥檚 role is to determine whether the diagnosis, tissue target, safety profile, and recovery plan support treatment within a coordinated, medically responsible framework.
